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KMID : 0370219800240020097
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Yakhak Hoeji
1980 Volume.24 No. 2 p.97 ~ p.100
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A Comparative Study of the Influence of Miflumic Acid and Phenylbutazone on Wafarin-Plasma Protein Binding
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조윤성/Chough YS
양중익/Yang JI
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Abstract
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To determine in vitro effects of phenylbutazone and niflumic acid on warfarin binding to rabbit serum protein, warfarin was added to the rabbit plasma, and the bound fraction was determined by warfarin-protein complex fluorescence. The bound fraction was decreased by phenylbtazone and niflumic acid. From this effect niflumic acid was found to have the more potent ability to displace warfarin from protein binding sites than phenylbutazone.
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KEYWORD
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